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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
Bieżący numer Archiwum Filmy Artykuły w druku O czasopiśmie Suplementy Rada naukowa Recenzenci Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
SCImago Journal & Country Rank
2/2009
vol. 111
 
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Artykuł oryginalny

Rozkład genotypów polimorfizmu C-460T genu naczyniowo-śródbłonkowego czynnika wzrostu w zwyrodnieniu plamki związanym z wiekiem

Jacek P. Szaflik
1
,
Janusz Błasiak
2
,
Anna Krzyżanowska
1
,
Małgorzata Zaraś
1
,
Katarzyna Janik-Papis
2
,
Anna I. Borucka
1
,
Katarzyna Woźniak
2
,
Jerzy Szaflik
1

  1. Ophthalmology Department, Medical University of Warsaw, Warsaw, Poland
  2. Department of Molecular Genetics, University of Lodz, Lodz, Poland
Klinika Oczna 2009, 111 (2): 125-127
Data publikacji online: 2009/07/06
Pełna treść artykułu Pobierz cytowanie
 
Wstęp
To assess the association between genotypes and alleles of the C-460T polymorphism of the vascular endothelial growth factor (VEGF) gene and the risk of wet form of age-related macular degeneration (AMD).

Materiał i metody
100 patients with clinically diagnosed wet form of AMD and 104 healthy individuals were enrolled in this study. The patients were diagnosed by optical coherence tomography, fluorescein angiography and indocyanin green angiography. The allele-specific polymerase chain reaction was used to determine the genotypes of the C-460T polymorphism of the VEGF gene. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a logistic regression model to assess the assoctiation betweeen genotypes of the C-460T polymorphism and AMD occurrence.

Wyniki
A difference was observed in the genotype distributions between patients and controls. An association (OR 3.04, 95% CI 1.65-5.60) was found between wet form of AMD and the C/T genotype. On the other hand, the T/T genotype displayed the protective effect against the disease.

Wnioski
The C-460T polymorphism of the endothelial growth factor can be considered as a potential marker for the wet form of age-related macular degeneration.



Introduction
To assess the association between genotypes and alleles of the C-460T polymorphism of the vascular endothelial growth factor (VEGF) gene and the risk of wet form of age-related macular degeneration (AMD).

Material and methods
100 patients with clinically diagnosed wet form of AMD and 104 healthy individuals were enrolled in this study. The patients were diagnosed by optical coherence tomography, fluorescein angiography and indocyanin green angiography. The allele-specific polymerase chain reaction was used to determine the genotypes of the C-460T polymorphism of the VEGF gene. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a logistic regression model to assess the assoctiation betweeen genotypes of the C-460T polymorphism and AMD occurrence.

Results
A difference was observed in the genotype distributions between patients and controls. An association (OR 3.04, 95% CI 1.65-5.60) was found between wet form of AMD and the C/T genotype. On the other hand, the T/T genotype displayed the protective effect against the disease.

Conclusions
The C-460T polymorphism of the endothelial growth factor can be considered as a potential marker for the wet form of age-related macular degeneration.

słowa kluczowe:

zwyrodnienie plamki związane z wiekiem, AMD, naczyniowo-śródbłonkowy czynnik wzrostu, VEGF, polimorfizm genetyczny

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