eISSN: 2354-0265
ISSN: 2353-6942
Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
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3/2021
vol. 15
 
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abstract:
Original paper

INFLUENCE OF L-TRYPTOPHAN AND ZINC ASPARTATE ON THE SENSITIVITY OF GRAM-NEGATIVE MICROORGANISMS TO DOXYCYCLINE

Tatiana Artyukh
1
,
Tatiana Sokolova
1

  1. Department of Microbiology, Virology and Immunology, Grodno State Medical University, Grodno, Belarus
Health Prob Civil. 2021; 15(3): 242-248
Online publish date: 2021/10/05
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Background
With an increase in antibiotic resistance in microorganisms, increasing the effectiveness of antibiotic therapy has become a crucial task for medical and pharmaceutical sciences. One possible way to increase the effectiveness of antibiotic therapy is to monitor biologically active substances like amino acids for their capability of increasing the activity of antibiotics. This research aimed to study the effects of tryptophan and zinc aspartate on the activity of doxycycline in relation to E. coli and P. aeruginosa.

Material and methods
The in vitro serial dilution method was used to determine the minimum inhibitory concentration (MIC) of doxycycline independently and in combination with tryptophan and zinc aspartate, for E. coli and P. aeruginosa.

Results
Tryptophan and zinc aspartate at a concentration of 2 μg/ml significantly increased the antibiotic activity of doxycycline against E. coli and P. aeruginosa (p<0.0001).

Conclusions
Biologically active substances, tryptophan and zinc aspartate have a modulating effect on the antibiotic sensitivity of microorganisms towards antibacterial drugs like doxycycline.

keywords:

zinc aspartate, doxycycline, minimum inhibitory concentration, tryptophan, antibiotic resistance


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